Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related changes in human thymus.

J Singh, A K Singh

    Clinical and Experimental Immunology
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Aging thymic tissue shows parenchymal atrophy and a decline in E-rosette-forming cells, replaced by null lymphoid cells. These age-related changes in the thymus may impact immune function independently.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Haemodynamic effects of pan masala in healthy volunteers.

    The Journal of the Association of Physicians of India·2001
    Same author

    A randomized comparison of classical mode of administration of amphotericin B with its newer modes of administration in kala-azar.

    The Journal of the Association of Physicians of India·2001
    Same author

    Relaxin decreases renal interstitial fibrosis and slows progression of renal disease.

    Kidney international·2001
    Same author

    A polystyrene based membrane electrode for cadmium(II) ions.

    Fresenius' journal of analytical chemistry·2001
    Same author

    The circadian pattern of ischaemic heart disease events in Indian population.

    The Journal of the Association of Physicians of India·2001
    Same author

    Amberlite XAD-7 impregnated with Xylenol Orange: a chelating collector for preconcentration of Cd(II), Co(II), Cu(II), Ni(II), Zn(II) and Fe(III) ions prior to their determination by flame AAS.

    Fresenius' journal of analytical chemistry·2001

    Area of Science:

    • Immunology
    • Gerontology
    • Cell Biology

    Background:

    • The thymus plays a crucial role in T-cell maturation and immune system regulation.
    • Age-related changes in the thymus, known as thymic involution, affect immune competence.
    • Understanding these changes is vital for addressing age-associated immune decline.

    Purpose of the Study:

    • To investigate age-related changes in thymic parenchyma and cell surface characteristics.
    • To correlate thymic involution with alterations in specific immune cell populations.
    • To assess the independence of observed parenchymal and cellular changes.

    Main Methods:

    • Analysis of thymic biopsies from patients undergoing open heart surgery.
    • Histopathological examination for signs of parenchymal atrophy.

    Related Experiment Videos

  • Flow cytometry or similar techniques to quantify E-rosette-forming cells and null lymphoid cells.

    • Main Results:

    • Significant age-related atrophy of the thymic parenchyma was observed.
    • A continuous decrease in E-rosette-forming cells was noted with increasing age.
    • An increasing proportion of 'null' lymphoid cells replaced E-rosette-forming cells, independent of parenchymal changes.

    Conclusions:

    • Thymic involution involves both parenchymal atrophy and shifts in lymphoid cell populations.
    • The decline in E-rosette-forming cells and rise of null cells occur independently of parenchymal involution.
    • These age-associated thymic alterations have implications for host immune mechanisms.