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Published on: March 6, 2019

Pigmented skin lesions in black newborn infants

J N Fox, R G Walton, B Gottlieb

    Cutis
    |October 1, 1979
    PubMed

    Insights

    Congenital pigmented lesions are common in Black newborns, with over half exhibiting these marks. Histological analysis revealed lentigo as the most frequent finding, highlighting unique patterns in neonatal skin.

    Area of Science:

    • Dermatology
    • Neonatology
    • Pediatric Pathology

    Background:

    • Congenital pigmented lesions in newborns require accurate characterization.
    • Previous studies on neonatal pigmented lesions in Black infants are limited.
    • Understanding the incidence and histology of these lesions is crucial for clinical management.

    Purpose of the Study:

    • To investigate the incidence and clinical patterns of congenital pigmented lesions in Black newborn infants.
    • To determine the histological subtypes and distribution of nevus cell theques.
    • To assess the correlation between clinical appearance and histological classification.

    Main Methods:

    • Prospective examination of 100 Black newborn infants for pigmented lesions.
    • Clinical documentation of lesion characteristics, including pattern and grouping.
    • Histopathological analysis of biopsy specimens from 32 selected lesions.

    Main Results:

    • A significantly higher incidence of congenital pigmented lesions (51%) was observed compared to prior reports.
    • The most frequent histological finding was lentigo (26 lesions), followed by melanocytic nevi (4 lesions) and ephelides (2 lesions).
    • Melanocytic nevi were predominantly of the junctional type and small in diameter; clinical appearance was not a reliable indicator for classification.

    Conclusions:

    • Congenital pigmented lesions are highly prevalent in Black newborns.
    • Lentigo is the predominant histological diagnosis, with a notable pattern of grouped macules.
    • Histopathological examination is essential for accurate classification of neonatal pigmented lesions, as clinical presentation can be misleading.

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