Drug-induced toxic epidermal necrolysis in children. Report of two cases

Two cases of toxic epidermal necrolysis occurring in children are presented herein. In both, multiple drugs were administered before the onset of the skin eruption. Cultures for staphylococcus were negative. Histopathologic examination of the first case revealed separations at the dermal-epidermal junction. While more commonly due to staphylococcal exfoliatoxin, a drug must be ruled out as the cause of toxic epidermal necrolysis in children.