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Left ventricular pump function in effort angina.

P Carlens, T Hindmarsh, A Holmgren

    European Journal of Cardiology
    |December 1, 1979
    PubMed
    Summary
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    Exercise significantly impairs left ventricular function in patients with angina pectoris. Left ventricular stroke work index decreases during exertion, especially in those with severe coronary disease or prior heart attack.

    Area of Science:

    • Cardiology
    • Cardiovascular Physiology

    Background:

    • Ischemic heart disease often compromises left ventricular pump function.
    • Exercise can exacerbate these functional deficits, leading to angina pectoris.

    Purpose of the Study:

    • To investigate the sequential decline in left ventricular pump function during exercise-induced angina pectoris.
    • To assess hemodynamic parameters under stress in patients undergoing evaluation for aortocoronary bypass surgery.

    Main Methods:

    • Studied 20 patients undergoing evaluation for aortocoronary bypass surgery.
    • Measured left ventricular pressure and cardiac output (thermodilution) during exercise.
    • Calculated left ventricular stroke work and power.

    Main Results:

    Related Experiment Videos

    • Left ventricular end-diastolic pressure increased progressively during exercise.
    • Left ventricular stroke work index initially rose then fell, preceding angina onset.
    • Patients exhibited lower stroke work index during exercise compared to normal subjects.
    • Higher coronary scores and prior myocardial infarction correlated with reduced exercise stroke work index.

    Conclusions:

    • Exercise-induced angina is associated with significant deterioration of left ventricular pump function.
    • Hemodynamic assessment during stress is crucial for identifying functional impairment in ischemic heart disease.
    • Coronary artery disease severity and history of infarction impact exercise capacity and ventricular performance.