Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disposition of morphine in man.

S Spector, E S Vesell

    Science (New York, N.Y.)
    |October 22, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Morphine

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Safety issues of maternal drug therapy during breastfeeding.

    Clinical pharmacology and therapeutics·2008
    Same author

    Recollections from the Kunkel laboratory, 1956-1958.

    Lupus·2003
    Same author

    NIH budget grows, but not R01 success rates.

    Science (New York, N.Y.)·2001
    Same author

    The pursuit of clinical truth: role of epidemiology/observation studies.

    Journal of clinical pharmacology·2000
    Same author

    Advances in pharmacogenetics and pharmacogenomics.

    Journal of clinical pharmacology·2000
    Same author

    Studies on pyrazinoylguanidine: a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus.

    Toxicology·2000

    Area of Science:

    • Pharmacokinetics
    • Analytical Chemistry

    Background:

    • Morphine is a widely used analgesic.
    • Understanding its metabolic fate is crucial for clinical application.

    Purpose of the Study:

    • To investigate the disposition of morphine in humans.
    • To quantify morphine serum concentrations over time after intravenous administration.

    Main Methods:

    • Radioimmunoassay was used to measure morphine levels.
    • A single intravenous dose of morphine (10 mg/70 kg) was given to 10 healthy males.

    Main Results:

    • Serum morphine concentrations showed a multiphasic decline.
    • Morphine or its metabolites were detectable in blood for up to 48 hours post-dose.

    Conclusions:

    • The disposition of morphine is complex, involving multiple elimination phases.
    • Morphine and its metabolites have a prolonged presence in the body after a single dose.