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Depression and cancer: a follow-up study.

F A Whitlock, M Sisking

    Psychological Medicine
    |November 1, 1979
    PubMed
    Summary

    This study found a significantly higher-than-expected cancer death rate in men diagnosed with depression. Further research is needed to explore the link between affective disorders and malignant neoplasms.

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    Hypoalgesia in depressive illness.

    The British journal of psychiatry : the journal of mental science·1982

    Area of Science:

    • Psychiatry
    • Oncology
    • Epidemiology

    Background:

    • Depression (major depressive disorder) is a common mental health condition.
    • Understanding comorbidities and mortality risks in depression patients is crucial.
    • Previous research suggests potential links between mental health and physical diseases.

    Purpose of the Study:

    • To investigate cancer mortality rates in a cohort of patients with a primary diagnosis of depression.
    • To determine if cancer deaths are significantly higher than expected in this population.
    • To explore potential associations between affective disorders and the development of malignant neoplasms.

    Main Methods:

    • A longitudinal follow-up study was conducted.
    • 129 patients (39 male, 90 female) aged 40+ with a primary depression diagnosis were monitored.
    • Follow-up duration ranged from 2 1/3 to 4 years.

    Main Results:

    • A total of 18 deaths occurred during the follow-up period (9 male, 9 female).
    • Six patients (5 male, 1 female) died from cancer that was undiagnosed at psychiatric admission.
    • The observed cancer mortality among males was significantly higher than expected.

    Conclusions:

    • There is a statistically significant elevation in cancer mortality among men with depression.
    • The findings suggest a potential relationship between affective disorders and the occurrence of malignant neoplasms.
    • Further investigation into the underlying mechanisms connecting depression and cancer is warranted.

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