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[Progress and developments in insulin therapy].

E R Froesch, G Blatter, R Candinas

Schweizerische Medizinische Wochenschrift

|December 1, 1979

Summary

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Insulin therapy for diabetes has seen slow progress. A programmable insulin pump offers improved blood sugar control without hypoglycemia, but catheter issues need resolution for routine use.

Area of Science:

Endocrinology
Metabolic Diseases
Pharmacology

Context:

Diabetes mellitus management has evolved since insulin's discovery.
Subcutaneous insulin injections and current technologies like the artificial pancreas have limitations.
Intravenous insulin administration is crucial for diabetic coma management.

Purpose:

To evaluate a programmable flexible open-loop insulin infusion system for diabetes management.
To assess the efficacy and safety of a novel insulin delivery method.
To compare the new approach with existing diabetes therapies.

Summary:

A programmable insulin pump allows variable basal rates (0.25-2 U/h) and bolus infusions (2-10 U/h) for one hour.
This system demonstrated successful blood glucose control in diabetic patients without observed hypoglycemic reactions.

Related Experiment Videos

Current challenges involve technical issues with the infusion catheter, hindering routine clinical application.

Impact:

This programmable insulin pump represents a promising therapeutic approach for improved diabetes control.
Successful implementation could enhance patient quality of life and reduce diabetes-related complications.
Further development is needed to overcome technical hurdles for widespread adoption.