Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies of the thyroid function in children with Down's syndrome.

B J Schmidt, N Carvalho, C C Ortega

    Arquivos De Neuro-Psiquiatria
    |March 1, 1975
    PubMed
    Summary

    Thyroid function in Down syndrome patients showed no significant differences compared to siblings, except for a slight delay in iodine-131 uptake. This suggests a compensated, though potentially slower, thyroid response in individuals with Down syndrome.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Model-based evaluation of the efficacy and safety of nivolumab once every 4 weeks across multiple tumor types.

    Annals of oncology : official journal of the European Society for Medical Oncology·2020
    Same author

    Analysis of genetic variability of commercial melon cultivars using SSR molecular markers.

    Genetics and molecular research : GMR·2017
    Same author

    Quantitative Systems Pharmacology: A Case for Disease Models.

    Clinical pharmacology and therapeutics·2016
    Same author

    The wide POLG-related spectrum: An integrated view.

    Journal of the neurological sciences·2016
    Same author

    Systems biology for simulating patient physiology during the postgenomic era of medicine.

    CPT: pharmacometrics & systems pharmacology·2014
    Same author

    Evaluation of current approaches to stream classification and a heuristic guide to developing classifications of integrated aquatic networks.

    Environmental management·2014

    Area of Science:

    • Endocrinology
    • Genetics
    • Nuclear Medicine

    Background:

    • Down syndrome is associated with various health complications, including potential thyroid dysfunction.
    • Understanding thyroid function in Down syndrome is crucial for comprehensive patient care.

    Purpose of the Study:

    • To investigate and compare thyroid function, including triiodothyronine (T-3), tetraiodothyronine (T-4), and iodine-131 (I-131) uptake, between patients with Down syndrome and their unaffected siblings.

    Main Methods:

    • Assessed thyroid hormones (T-3, T-4) and thyroidal I-131 uptake at 2 and 24 hours post-isotope administration.
    • Compared results between Down syndrome patients and their clinically normal siblings.

    Main Results:

    • No significant differences were observed in overall thyroid function (T-3, T-4, 24-hour I-131 uptake) between the two groups.

    Related Experiment Videos

  • A statistically significant difference (P < 0.01) was noted in the 2-hour I-131 uptake, indicating a potentially slower initial thyroid response in Down syndrome patients.

    • Conclusions:

    • The findings suggest a potentially slower, but ultimately compensated, thyroid gland response in individuals with Down syndrome.
    • The hypothalamus-pituitary-thyroid axis may exhibit altered dynamics in Down syndrome, requiring further investigation.