[Biogenic amine deamination in experimental tuberculosis]

Stimulation of lipid peroxidation /increase in content of conjugated dienes and of malone dialdehyde/, which was prevented by administration of isoniazid or sodium thiosulphate, was detected in mitochondrial fraction of liver tissue obtained from rats with tuberculosis of lungs. At the same time, in the mitochondrial fraction a significant decrease in tyramine and serotonin deamination rates and an increase in histamine, lysine and putrescine deamination rates were observed. The altered ratio of the deamination rates of the nitrogenous compounds may be prevented by administration of isoniazid and sodium thiosulphate into the animals. A hypothesis is discussed on the possible significance of qualitative alteration /transformation/ in catalytic properties of the mitochondrial monoamine oxidase induced by the stimulation of lipid peroxidation as a cause underlying the reversible impairments in ratios of rates of the nitrogenous compounds deamination in tuberculosis.