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Eosinophilic gastroenteritis--a complex disease entity
The American Journal of Medicine
|December 1, 1979
Summary
Eosinophilic gastroenteritis, a poorly understood gastrointestinal disorder, involves eosinophil buildup in the bowel. While food withdrawal is inconsistent, oral steroids may help manage symptoms.
Area of Science:
- Gastroenterology
- Immunology
- Allergy
Background:
- Eosinophilic gastroenteritis is often misdiagnosed as a simple food allergy.
- It presents with peripheral eosinophilia, gastrointestinal symptoms, and eosinophilic infiltration of the bowel wall.
Observation:
- The disease shows inconsistent responses to dietary elimination protocols.
- Some patients exhibit specific Immunoglobulin E (IgE) antibodies to food antigens.
Findings:
- A proposed mechanism involves IgE, mast cells, and the release of slow-reacting substance of anaphylaxis (SRS-A).
- This leads to eosinophil recruitment to the gastrointestinal tract.
Implications:
- Understanding the pathophysiology is crucial for effective treatment strategies.
- Oral corticosteroids show promise in managing eosinophilic gastroenteritis, warranting further controlled trials.