Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in the diastolic pressure-diameter relation after ventricular function curves.

G A Misbach, S A Glantz

    The American Journal of Physiology
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cardiovascular Effects of Secondhand Smoke Nearly as Large as Those of Smoking-and How about Renal Effects?: Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking. Am Heart J 111: 2684-2698, 2005.

    Journal of the American Society of Nephrology : JASN·2023
    Same author

    Enacting tobacco taxes by direct popular vote in the United States: lessons from 20 years of experience.

    Tobacco control·2009
    Same author

    Civil society and the negotiation of the Framework Convention on Tobacco Control.

    Global public health·2009
    Same author

    Signed, sealed and delivered: "big tobacco" in Hollywood, 1927-1951.

    Tobacco control·2008
    Same author

    Evidence secondhand smoke causes breast cancer in 2005 stronger than for lung cancer in 1986.

    Preventive medicine·2008
    Same author

    Eliminating child labour in Malawi: a British American Tobacco corporate responsibility project to sidestep tobacco labour exploitation.

    Tobacco control·2006

    Ventricular function curves, used to assess heart systolic performance, are misleading when using end-diastolic pressure. Using end-diastolic diameter provides a more accurate measure of cardiac contractility.

    Area of Science:

    • Cardiology
    • Physiology
    • Biomedical Engineering

    Background:

    • Systolic performance is influenced by end-diastolic muscle fiber length, contractility, and afterload.
    • Conventional ventricular function curves rely on end-diastolic pressure, assuming a constant relationship with end-diastolic dimensions (fiber length).
    • This assumption has been challenged, suggesting that changes in the diastolic pressure-dimension relationship can affect these curves.

    Purpose of the Study:

    • To investigate the impact of altered diastolic pressure-dimension relationships on ventricular function curves.
    • To determine whether end-diastolic pressure or end-diastolic diameter is a more reliable index for assessing systolic performance and contractility.

    Main Methods:

    • Measurements of ventricular pressures and dimensions were taken in six open-chest dogs.

    Related Experiment Videos

  • The pericardium was opened to modify diastolic pressure-dimension relationships while keeping afterload constant.
  • Systolic performance was quantified as developed pressure multiplied by diameter change during systole.

    • Main Results:

    • Plotting systolic performance against end-diastolic pressure yielded distinct curves with the pericardium open versus closed, suggesting altered contractility.
    • Plotting systolic performance against end-diastolic diameter resulted in a single curve, irrespective of pericardial status, indicating no change in contractility.
    • This demonstrates that changes in the diastolic pressure-dimension relationship shift conventional ventricular function curves based on pressure.

    Conclusions:

    • End-diastolic diameter is a more accurate indicator of systolic performance and contractility than end-diastolic pressure.
    • Conventional ventricular function curves based on end-diastolic pressure can be misleading due to variations in the diastolic pressure-dimension relationship.
    • Understanding the diastolic pressure-dimension relationship is crucial for accurate assessment of cardiac function.