Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between steroidreceptors.

J P Janssens, J Van Dam, C Wittevrongel

    Annales D'Endocrinologie
    |January 1, 1979
    PubMed
    Summary

    Estradiol and progesterone receptor interactions are key in hormone-sensitive breast cancers. Detecting both receptors can predict treatment response, but preoperative irradiation may negatively impact progesterone receptor levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mental stress may cause high gas consumption and accelerated heart rate in fast-descending divers.

    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2019
    Same author

    Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    Medium-term cost-effectiveness of an automated non-invasive ventilation outpatient set-up versus a standard fixed level non-invasive ventilation inpatient set-up in obese patients with chronic respiratory failure: a protocol description.

    BMJ open·2015
    Same author

    Gait abnormalities in obstructive sleep apnea and impact of continuous positive airway pressure.

    Respiratory physiology & neurobiology·2014
    Same author

    Rapid multiexcitation fluorescence spectroscopy system for in vivo tissue diagnosis.

    Applied optics·2010
    Same author

    Proposal for a systematic analysis of polygraphy or polysomnography for identifying and scoring abnormal events occurring during non-invasive ventilation.

    Thorax·2010

    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Estradiol receptor (ER) and progesterone receptor (PR) interactions are established in uterine tissues.
    • The "priming effect" of estradiol, involving ER and PR, is hypothesized to occur in human and rat mammary tumors.
    • Assessing both ER and PR is crucial for understanding hormone receptor activity in breast cancer.

    Purpose of the Study:

    • To investigate the role of progesterone receptors in conjunction with estrogen receptors in human and rat mammary tumors.
    • To determine if combined receptor detection enhances the prediction of hormone sensitivity.
    • To examine the impact of preoperative irradiation on progesterone receptor levels in breast tumors.

    Main Methods:

    • Analysis of estrogen receptor and progesterone receptor expression in mammary tumor samples.
    Keywords:
    BiologyBreast CancerCancerDiseasesEndocrine SystemEstrogens--therapeutic useHormonesNeoplasmsPhysiologyProgestational HormonesProgesterone--therapeutic use

    Related Experiment Videos

  • Evaluation of the "priming effect" of estradiol in tumor models.
  • Assessment of progesterone receptor titers following preoperative irradiation.

    • Main Results:

    • Detecting progesterone receptors alongside estrogen receptors confirms estrogen receptor activity.
    • This dual receptor detection may improve the prediction of hormone sensitivity in receptor-positive tumors.
    • Preoperative irradiation was associated with negative progesterone receptor titers in human breast tumors.

    Conclusions:

    • Combined detection of estrogen and progesterone receptors provides a more comprehensive assessment of hormone activity in breast cancer.
    • This approach holds potential for improving patient selection for hormone therapy.
    • Preoperative irradiation poses a potential challenge by possibly reducing progesterone receptor levels, impacting treatment decisions.