Interferon response to human diploid cell strain rabies vaccines in man

Circulating interferon was found in volunteers immunized with 3.0 ml and 1.0 ml doses of human diploid cell strain (HDCS) rabies vaccines. Peak interferon titres were observed 17--25 hours after primary vaccination and the response diminished upon revaccination. The response was dose-related and did not correlate with the antigenic value of the vaccines or with the titre of infections virus in the vaccines before inactivation.