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Related Experiment Videos

Lactoferrin turnover in man.

R M Bennett, T Kokocinski

    Clinical Science (London, England : 1979)
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Lactoferrin is quickly cleared from plasma, with iodine excreted rapidly. Iron from lactoferrin is processed slowly, accumulating in organs before red blood cell incorporation, indicating its role in iron metabolism and neutrophil turnover.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Immunology

    Background:

    • Lactoferrin is an iron-binding protein crucial for immune function.
    • Understanding lactoferrin's metabolic fate is key to its physiological roles.

    Purpose of the Study:

    • To investigate the turnover and catabolism of lactoferrin in adult humans.
    • To determine the fate of iron and iodine derived from lactoferrin.

    Main Methods:

    • Administered 125I-labelled and 59Fe-labelled lactoferrin to adult subjects.
    • Performed simultaneous organ radioactivity counting.
    • Conducted ferrokinetic studies.

    Main Results:

    • Lactoferrin exhibited rapid plasma elimination (mean fractional catabolic rate 5.7/day).

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  • 125I was rapidly excreted as free iodine in urine, suggesting catabolism in liver and spleen.
  • 59Fe persisted in organs for weeks, slowly transferring to bone marrow and erythrocytes.

    • Conclusions:

    • Lactoferrin undergoes rapid catabolism, with iodine released quickly and iron utilized for erythropoiesis.
    • A derived neutrophil turnover, potentially representing intravascular senescence, was calculated.
    • These findings elucidate lactoferrin's role in iron homeostasis and neutrophil dynamics.