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[Paget's osteodystrophia deformans. Occurrence, clinical aspects and complications]
Deutsche Medizinische Wochenschrift (1946)
|December 28, 1979
Summary
This study analyzed 60 Paget's disease of bone patients, finding common bone involvement and elevated biochemical markers. Calcitonin treatment was deemed suitable for 41 patients after thorough evaluation.
Area of Science:
- Orthopedics
- Endocrinology
- Radiology
Context:
- Paget's disease of bone is a chronic condition affecting bone remodeling.
- The study analyzed 60 patients with Paget's disease, encompassing both monostotic and polyostotic forms.
- Commonly affected sites include the pelvis, tibia, spine, skull, and sacrum.
Purpose:
- To characterize the clinical and radiological manifestations of Paget's disease.
- To evaluate biochemical markers and patient stratification for treatment.
- To determine the suitability of calcitonin treatment based on disease characteristics.
Summary:
- The study identified 33 monostotic and 27 polyostotic cases in 60 patients, with elevated alkaline phosphatase and hydroxyproline excretion in most.
- Four patient groups were distinguished within monostotic cases based on symptoms.
- Polyostotic cases showed symptomatic and asymptomatic bone involvement.
- Calcitonin treatment was indicated in 41 patients after comprehensive evaluation.
Impact:
- Provides insights into the diverse presentation of Paget's disease.
- Highlights the importance of thorough patient assessment for treatment decisions.
- Informs clinical practice regarding the management of Paget's disease with calcitonin.