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Diuresis during fluid infusion : buffer nerve and spinal influences on it
Indian Journal of Physiology and Pharmacology
|July 1, 1979
Summary
The type of anesthesia and intravenous fluid composition significantly impact infusion-induced diuresis in dogs. Paraldehyde anesthesia exhibits an antidiuretic effect, while chloralose/urethane anesthesia shows varied responses to fluid types and surgical interventions.
Area of Science:
- Physiology
- Pharmacology
Background:
- Diuresis, or urine production, is crucial for fluid balance and waste excretion.
- Understanding factors influencing diuresis is vital in veterinary medicine and research.
Purpose of the Study:
- To investigate the effects of different anesthetic agents and intravenous fluids on infusion-induced diuresis in dogs.
- To explore the role of vagotomy and carotid sinus denervation in modulating diuretic responses.
Main Methods:
- Dogs were anesthetized using either paraldehyde (PLD) or chloralose and urethane (C & U).
- Infusions of Normal Saline (NS), Ringer-Locke (RL), and tender coconut water (TCW) were administered at a slow rate (0.5 ml/kg/min).
- Experiments included vagotomized, carotid sinus denervated, and spinal dog models.
Main Results:
- Paraldehyde anesthesia resulted in significantly lower urine output compared to C & U anesthesia.
- The diuretic efficacy varied: RL < NS < TCW in PLD groups and NS < TCW < RL in C & U groups.
- Vagotomy and carotid sinus denervation in C & U anesthetized dogs increased diuresis, but combined surgery decreased it. Spinal dogs showed minimal diuresis.
Conclusions:
- Anesthetic type and fluid composition are key determinants of infusion-induced diuresis.
- Paraldehyde anesthesia possesses an antidiuretic effect not reversed by vagotomy.
- Nervous system interventions (vagotomy, CS denervation) differentially affect diuresis depending on the anesthetic used.