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[Unstable diabetes (author's transl)].

J A Amado Señaris

    Medicina Clinica
    |November 10, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Unstable diabetes presents unpredictable blood sugar fluctuations, making metabolic control difficult. Key factors include low insulin reserve and high-affinity anti-insulin antibodies, complicating treatment.

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    Area of Science:

    • Endocrinology and Metabolism
    • Diabetology

    Context:

    • Unstable diabetes is defined by erratic glycemic variations, hindering effective metabolic management.
    • Various metrics like continuous glucose monitoring and M value assess instability.
    • Instability can be transient, often due to external factors or poor management, or permanent.

    Purpose:

    • To explore the characteristics and pathogenic factors of unstable diabetes.
    • To discuss the challenges in evaluating and managing glycemic instability.
    • To highlight the role of the Somogyi effect in unstable diabetes.

    Summary:

    • Unstable diabetes involves unpredictable glycemia, complicating metabolic control.
    • The Somogyi effect is a crucial consideration. Primary pathogenic factors may include absent pancreatic insulin reserve and high-affinity anti-insulin antibodies.

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  • Secondary factors like glucagon and growth hormone play a lesser role. Current treatments remain unsatisfactory.
  • Impact:

    • Improved understanding of unstable diabetes pathophysiology.
    • Highlights the need for better diagnostic criteria and management strategies.
    • Informs future research directions for more effective unstable diabetes treatments.