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Growth hormone response to continuous and intermittent exercise.

A Karagiorgos, J F Garcia, G A Brooks

Medicine and Science in Sports

|January 1, 1979

Summary

Human growth hormone (hGH) secretion during exercise is not directly linked to anaerobic metabolism or blood lactic acid (LA) levels. Exercise increases hGH, but its rise doesn't correlate with lactate or other metabolic markers.

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Area of Science:

Exercise Physiology
Endocrinology
Metabolic Research

Background:

Human growth hormone (hGH) plays a role in metabolic regulation.
The relationship between exercise intensity, anaerobic metabolism, and hGH release is not fully understood.
Lactic acid (LA) is a key indicator of anaerobic metabolism during exercise.

Purpose of the Study:

To investigate the hypothesis that hGH secretion during exercise is associated with anaerobic metabolism, indicated by blood lactic acid (LA).
To compare hGH and metabolic responses to continuous exercise (CE) versus intermittent exercise (IE).

Main Methods:

Ten healthy males (20-30 years) underwent 40 minutes of continuous cycle ergometer exercise (CE) and intermittent exercise (IE).
IE involved 1-minute on/off intervals at a higher work rate than CE.
Blood samples were analyzed for hGH, lactic acid (LA), pyruvate (PY), free fatty acids, alanine, and glucose.
Rectal temperature (T) and oxygen deficit (O2 deficit) were also monitored.

Main Results:

hGH levels increased significantly after a lag period in both CE and IE, with a trend towards higher levels during IE.
Lactic acid (LA) and pyruvate (PY) increased continuously during IE, reaching levels three times higher than during CE.
CE resulted in higher peak levels of free fatty acids compared to IE.
No significant physiological correlation was found between hGH levels and LA, PY, alanine, glucose, rectal T, or O2 deficit.

Conclusions:

The hGH response to exercise is not directly driven by anaerobic metabolism or elevated lactic acid.
Different exercise protocols (CE vs. IE) elicit distinct metabolic profiles but do not significantly alter the hGH response in a correlated manner.
Further research is needed to elucidate the precise mechanisms regulating hGH secretion during physical exertion.

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