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Immunological tolerance and dogma.

N M Vaz

    Medical Hypotheses
    |September 1, 1979
    PubMed
    Summary

    Oral tolerance, where adult organisms adapt to food proteins, is a key immune function. This immune process challenges existing immunological paradigms, suggesting a need for revision in current thinking.

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    Area of Science:

    • Immunology
    • Immunological tolerance

    Background:

    • Immunization and tolerance induction are complementary aspects of immune responsiveness.
    • Adult organisms can develop tolerance to ingested food proteins, a phenomenon known as oral tolerance.
    • This concept has historically been overlooked in immunological discourse.

    Purpose of the Study:

    • To highlight the significance of oral tolerance in immune responsiveness.
    • To argue that oral tolerance challenges current immunological paradigms.
    • To advocate for a revision of existing immunological frameworks.

    Main Methods:

    • Review of existing immunological principles.
    • Analysis of the concept of oral tolerance.
    • Argumentation based on established immunological knowledge.

    Main Results:

    • Oral tolerance is a natural phenomenon in adult organisms.
    • The established understanding of immune responsiveness may be incomplete.
    • Current immunological paradigms may not fully accommodate oral tolerance.

    Conclusions:

    • Oral tolerance is a crucial, yet often neglected, aspect of immune function.
    • The existence of oral tolerance necessitates a re-evaluation of immunological theories.
    • A revised understanding of immune responsiveness is required to integrate oral tolerance.

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