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Altered glucose tolerance in carbon disulfide exposed workers
Acta Diabetologica Latina
|July 1, 1979
Summary
Carbon disulfide (CS2) exposure significantly increases the risk of developing latent diabetes. Workers exposed to CS2 showed a much higher prevalence of impaired glucose tolerance compared to controls.
Area of Science:
- Occupational Health
- Endocrinology
- Toxicology
Background:
- Carbon disulfide (CS2) is an industrial solvent with known toxic effects.
- Previous studies suggest a potential link between CS2 exposure and metabolic disturbances.
Purpose of the Study:
- To investigate the prevalence of latent diabetes in workers exposed to carbon disulfide (CS2).
- To determine the correlation between CS2 exposure levels and glucose tolerance.
Main Methods:
- Oral cortisone glucose tolerance tests were conducted.
- 66 CS2-exposed workers were compared with 66 matched control subjects.
Main Results:
- A significantly higher prevalence of latent diabetes was observed in the CS2-exposed group (72.7%) compared to controls (16.7%).
- A significant positive correlation was found between blood glucose levels and the CS2 exposure index (p < 0.001).
Conclusions:
- Occupational exposure to carbon disulfide is associated with a substantially increased risk of latent diabetes.
- Potential mechanisms involving altered zinc and pyridoxine metabolism may contribute to CS2-induced glucose intolerance.