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Cortisol secretion following nomifensine administration in normal subjects
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
|November 1, 1979
Summary
Nomifensine, a catecholamine reuptake inhibitor, significantly decreased prolactin secretion in normal subjects. However, cortisol levels remained unaffected, suggesting limited impact on the ACTH-cortisol axis.
Area of Science:
- Neuroendocrinology
- Pharmacology
Background:
- The hypothalamic-pituitary-adrenal (HPA) axis regulates cortisol secretion.
- Dopaminergic pathways influence prolactin and cortisol release.
- Nomifensine inhibits catecholamine reuptake.
Purpose of the Study:
- To investigate the effects of nomifensine on prolactin and cortisol secretion.
- To explore the role of the hypothalamic dopaminergic system in regulating the ACTH-cortisol axis.
Main Methods:
- Oral administration of nomifensine to 12 healthy volunteers.
- Measurement of prolactin and cortisol levels before and after administration.
Main Results:
- A significant decrease in prolactin levels was observed in all subjects.
- Cortisol levels showed no significant change following nomifensine administration.
Conclusions:
- Nomifensine effectively suppresses prolactin secretion.
- The drug does not appear to significantly impact the ACTH-cortisol axis in normal individuals.