Antiglobulins in ankylosing spondylitis

An immunoadsorption technique was used to investigate the presence of antiglobulin factors in 28 patients with ankylosing spondylitis and 30 healthy individuals. Both groups were "sero-negative" by standard agglutination techniques. Whereas the controls were consistently negative, 18 of the 28 patients with ankylosing spondylitis had antiglobulins of the IgG class.