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Related Experiment Videos

Evolution and the need for ascorbic acid.

L Pauling

    Proceedings of the National Academy of Sciences of the United States of America
    |December 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Most animals can synthesize ascorbic acid (vitamin C), unlike humans. This suggests optimal vitamin C intake from raw plant foods is insufficient, recommending at least 2.3g daily for adults.

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    Proceedings of the National Academy of Sciences of the United States of America·1994

    Area of Science:

    • Biochemistry
    • Human Nutrition
    • Comparative Physiology

    Background:

    • Ascorbic acid (vitamin C) is essential for human health.
    • Unlike most animals, humans cannot synthesize ascorbic acid.
    • Dietary intake is the sole source of vitamin C for humans.

    Purpose of the Study:

    • To evaluate the optimal daily intake of ascorbic acid for adult humans.
    • To determine if typical diets provide sufficient vitamin C for peak health.
    • To understand the implications of limited exogenous ascorbic acid synthesis in humans.

    Main Methods:

    • Comparative analysis of vitamin C synthesis across animal species.
    • Nutritional assessment of ascorbic acid content in raw natural plant foods.
    • Calculation of optimal daily intake based on energy requirements.

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    Main Results:

    • Ascorbic acid synthesis is a capability limited to a few animal species.
    • Raw natural plant foods may not provide optimal levels of ascorbic acid.
    • An estimated daily intake of 2.3g or more is suggested for adults with a 2500 kcal/day requirement.

    Conclusions:

    • The human requirement for exogenous ascorbic acid is significant.
    • Current dietary intake of vitamin C may be suboptimal for achieving best health.
    • Higher daily intake of ascorbic acid is recommended for optimal human health.