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HL-A27 and anterior uveitis.

J C Woodrow, R Mapstone, J Anderson

    Tissue Antigens
    |September 1, 1975
    PubMed
    Summary

    The human leukocyte antigen (HLA)-B27 gene is strongly associated with non-granulomatous uveitis, found in over half of patients. This suggests a potential link between HLA-B27 and the development of certain types of uveitis.

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    Area of Science:

    • Ophthalmology
    • Immunogenetics
    • Rheumatology

    Background:

    • Non-granulomatous uveitis is an inflammatory eye condition with complex etiology.
    • Human Leukocyte Antigen (HLA) types are cell surface proteins crucial for immune response.
    • Previous studies suggest associations between certain HLA types and inflammatory diseases.

    Purpose of the Study:

    • To investigate the association between HLA-B27 and non-granulomatous uveitis.
    • To determine the prevalence of HLA-B27 in patients with non-granulomatous uveitis compared to controls.
    • To explore potential links between HLA-B27 and the pathogenesis of uveitis.

    Main Methods:

    • Human Leukocyte Antigen (HLA) typing was performed on 90 patients diagnosed with non-granulomatous uveitis.
    • Patient HLA types were compared to a control group.
    • Clinical histories were reviewed for associated conditions like ankylosing spondylitis and Reiter's syndrome.

    Main Results:

    • A significantly higher prevalence of HLA-B27 positivity was observed in patients with non-granulomatous uveitis (55.7%) compared to controls (8.2%).
    • Among patients with uveitis, 13 out of 16 with ankylosing spondylitis and 2 with Reiter's syndrome were HLA-B27 positive.
    • Twenty-eight HLA-B27 positive patients had no diagnosed rheumatic disease, indicating potential subclinical associations.

    Conclusions:

    • The human leukocyte antigen (HLA)-B27 antigen is strongly associated with non-granulomatous uveitis.
    • This association suggests a significant role for HLA-B27 in the pathogenesis of this specific type of ocular inflammation.
    • Further research is warranted to elucidate the precise mechanisms linking HLA-B27 to uveitis development.

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