[Comparative evaluation of biodestruction of polyurethanes synthetized on the basis of simple and complex polyesters]

In model liquids and experimental animals (rats, rabbits) with the aid of physico-mechanical and histological methods (using interferentially polarizating microscopy) a comparative evaluation was made of the biodestruction of polyurethanes from synthetized simple and complex polyesters. The tissue reaction to intra-abdominal, intramuscular and subcutaneous implantation of perforated stripes of A-19 and Nr. 36 polymer was moderate. Two weeks post-operative increased volumetric biodestruction of the polymers was observed. The course was different in various standards and depended upon the chemical structure of the polymers. Taking into account the slight macrophage tissue reaction, in counterdistinction to the significant volumetric biodestruction which envolved the entire width of the polymer strip, it is assumed that the destruction of the investigated polyurethane composition (adhesive KL-3) takes place by hydrolysis 3 to 6 months post-implant.