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Prostaglandin E antagonist activity of 11-deoxy-16,16-trimethyleneprostaglandin E1
Prostaglandins
|September 1, 1979
Abstract:
11-Deoxy-16,16-trimethyleneprostaglandin E1 is a potent inhibitor of prostaglandin E-induced contractions of the gerbil colon. The antagonism is directed specifically against the prostaglandin E receptor and is not manifested when contractions are induced by either prostaglandin F2 alpha or acetylcholine.