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Serum parathyroid hormone in X-linked hypophosphatemia
Science (New York, N.Y.)
|August 27, 1971
Summary
Serum parathyroid hormone levels are normal in untreated X-linked hypophosphatemic rickets. Phosphate supplementation increases parathyroid hormone, but it does not correct the kidney
Area of Science:
- Biochemistry
- Pediatric Endocrinology
- Nephrology
Background:
- X-linked hypophosphatemic rickets (XLH) is a genetic disorder affecting phosphate metabolism.
- Patients with XLH exhibit impaired renal tubular reabsorption of phosphate.
- The role of parathyroid hormone (PTH) in XLH pathophysiology is not fully understood.
Purpose of the Study:
- To investigate the relationship between serum immunoreactive parathyroid hormone (IPTH) levels and phosphate treatment in patients with XLH.
- To determine if endogenous IPTH influences the tubular reabsorption defect in XLH.
Main Methods:
- Measurement of serum IPTH levels in patients with XLH before and during phosphate salt treatment.
- Assessment of tubular reabsorption of phosphate in male patients.
Main Results:
- Serum IPTH levels were normal in untreated XLH patients.
- Phosphate salt administration led to an increase in serum IPTH.
- Endogenous IPTH did not alter the established defect in renal tubular phosphate reabsorption in male patients.
Conclusions:
- Serum IPTH is not elevated in untreated XLH.
- Phosphate therapy increases IPTH in XLH patients.
- The primary defect in phosphate handling in XLH is independent of endogenous IPTH levels.