Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new technique to increase coronary flow. Preliminary report.

S Moulopoulos, S Stamatelopoulos, D Boufas

    Artificial Organs
    |November 1, 1979
    PubMed
    Summary

    Researchers explored using cardiac contraction energy to boost coronary blood flow during systole. A novel device successfully increased coronary flow without raising aortic pressure, suggesting a new method for enhancing heart circulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Low prevalence of cardiac troponin T mutations in a Greek hypertrophic cardiomyopathy cohort.

    Heart (British Cardiac Society)·2005
    Same author

    Gastric adenocarcinoma in a patient under immunosuppressive and omeprazole treatment.

    Pharmacoepidemiology and drug safety·2004
    Same author

    Pneumonia due to Candida krusei.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2003
    Same author

    Arterial compliance is an independent factor predicting acute hemodynamic performance of intra-aortic balloon counterpulsation.

    The International journal of artificial organs·2001
    Same author

    Atrioventricular node modification in patients with chronic atrial fibrillation: role of morphology of RR interval variation.

    Circulation·2001
    Same author

    Association of serum nitric oxide levels with depressive symptoms: a study with end-stage renal failure patients.

    Psychotherapy and psychosomatics·2001

    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering

    Background:

    • Cardiac contraction generates energy to propel blood systemically.
    • Coronary blood flow is crucial for myocardial oxygenation.
    • Investigating methods to augment coronary perfusion during systole is of clinical interest.

    Purpose of the Study:

    • To determine if cardiac contraction energy can be redirected to enhance systolic coronary blood flow.
    • To evaluate novel devices designed to divert aortic flow towards coronary arteries.

    Main Methods:

    • Ten flow-diverting devices (I-X) were designed to minimally impact flow resistance.
    • Testing was conducted using a mock circulation system and in nine anesthetized dogs.
    • Device I, positioned above the aortic valve, was evaluated for its effect on coronary flow.

    Related Experiment Videos

    Main Results:

    • Device I significantly increased "coronary flow" by 11.69% (±1.97%, P < 0.005) in mock circulation.
    • Coronary sinus flow increased by 8.98% (±0.56%, P < 0.001) in anesthetized dogs.
    • These increases were achieved without a significant rise in mean aortic pressure or flow resistance.

    Conclusions:

    • It is possible to divert a portion of the aortic flow towards the coronary arteries.
    • This diversion can enhance coronary blood flow during systole without increasing mean aortic pressure.
    • The findings suggest a potential new approach for improving myocardial perfusion.