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Modification of cardiac function by synchronized oscillating acceleration.

A Bhattacharya, C F Knapp, E P McCutcheon

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |September 1, 1979
    PubMed
    Summary
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    External whole-body oscillating Acceleration Synchronized with the Electrocardiogram (EASE) minimally impacts cardiovascular responses when timed with systole. However, EASE significantly alters cardiovascular function when applied during diastole, suggesting diagnostic and therapeutic potential.

    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering
    • Exercise Physiology

    Background:

    • Cardiovascular (CV) responses to physical stressors require precise analysis.
    • External whole-body oscillating Acceleration Synchronized with the Electrocardiogram (EASE) is a novel physical stressor.
    • Understanding EASE's impact on CV function is crucial for its application.

    Purpose of the Study:

    • To analyze the sensitivity of selected cardiovascular responses to EASE.
    • To compare CV responses under different EASE timing protocols.
    • To assess the potential diagnostic and therapeutic applications of EASE.

    Main Methods:

    • Eight chronically instrumented dogs were subjected to EASE.
    • A sinusoidal acceleration waveform (+/- 0.75 G, 2-3 Hz) was applied along the spinal axis.

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  • CV responses were measured when EASE peak force coincided with early systole versus early diastole.

    • Main Results:

    • Minimal changes in myocardial oxygen consumption (MVo2), coronary flow (MCF), stroke volume (SV), cardiac work (CW), and left ventricular pressure derivative (dP/dt) were observed when EASE was synchronized with systole.
    • Maximal increases in MVo2, MCF, SV, CW, and dP/dt occurred when EASE was synchronized with diastole.
    • The magnitude of CV response was highly dependent on the phase of the cardiac cycle during EASE application.

    Conclusions:

    • EASE elicits variable cardiovascular responses based on its synchronization with the cardiac cycle.
    • The differential CV responses suggest EASE can be modulated for specific effects.
    • EASE demonstrates potential for diagnostic and therapeutic interventions in cardiovascular medicine.