Effect of concanavalin A on lysosomal enzyme content of Hela cells

Precoating Hela cells with concanavalin A (Con A) induces a decrease of lysosomal enzyme intracellular content, and correlatively increases the amount of these enzymes in the culture medium. Possible mechanisms of the lectin effect are discussed in relation to the hypothesis of the secretion-endocytosis cycle of lysosomal enzymes.