Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular hemodynamics during respiration.

J L Robotham, J Rabson, S Permutt

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multimodality imaging of an old organized hemopericardium.

    The Canadian journal of cardiology·2010
    Same author

    Schistosomal cor pulmonale: A fluke in the Fas lane?

    Respiration; international review of thoracic diseases·2004
    Same author

    Exhaled NO: first, hold your breath.

    Journal of applied physiology (Bethesda, Md. : 1985)·2001
    Same author

    Airways hyperresponsiveness and the effects of lung inflation.

    International archives of allergy and immunology·2001
    Same author

    High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma.

    American journal of respiratory and critical care medicine·2001
    Same author

    The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness.

    American journal of respiratory and critical care medicine·2001
    Same journal

    Metabolic control of cardiac output response to exercise in McArdle's disease.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Hypoxic insomnia: effects of carbon monoxide and acclimatization.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Quiet-breathing vs. panting methods for determination of specific airway conductance.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    A new method for raising neonatal rabbits in a hypoxic environment.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Modification of the cutaneous vascular response to exercise by local skin temperature.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Temperature regulation during treadmill exercise in the rat.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    See all related articles

    Inspiration decreases left ventricular stroke volume (LVSV) by increasing right-heart volume and left ventricular afterload. These factors, driven by falling pleural pressure, reduce cardiac output during breathing.

    Area of Science:

    • Cardiovascular Physiology
    • Respiratory Mechanics

    Background:

    • Inspiratory maneuvers can affect cardiac function.
    • Understanding the mechanisms behind the inspiratory fall in left ventricular stroke volume (LVSV) is crucial for respiratory and cardiac physiology.

    Purpose of the Study:

    • To investigate the mechanisms responsible for the inspiratory decrease in left ventricular stroke volume (LVSV).
    • To determine the roles of right-heart volume (RHV) and left ventricular (LV) afterload in this phenomenon.

    Main Methods:

    • Utilized a spontaneously breathing dog model on right-heart bypass (RHBP).
    • Controlled lung volume, pulmonary artery inflow, and right-heart volume (RHV).
    • Performed Mueller maneuvers with and without allowing RHV to increase as pleural pressure (Ppl) fell.

    Related Experiment Videos

    Main Results:

    • Left ventricular stroke volume (LVSV) significantly decreased in both experimental conditions.
    • A significant rise in transmural aortic diastolic pressure indicated increased LV afterload.
    • Transmural left ventricular filling pressure did not decrease, ruling out reduced pulmonary venous return as the primary cause.
    • LVSV reduction was greater when RHV was allowed to increase.

    Conclusions:

    • The inspiratory fall in pleural pressure (Ppl) increases both right-heart volume (RHV) and effective LV afterload.
    • These combined effects of increased RHV and LV afterload are the primary drivers for the inspiratory decrease in LVSV.
    • Reduced pulmonary venous return is not the main cause of inspiratory LVSV reduction.