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Perinatal asphyxia I: Pathogenesis of multisystemic sequelae.

A K Fomufod, F Rahbar, P L White

    Journal of the National Medical Association
    |October 1, 1979
    PubMed
    Summary
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    Perinatal asphyxia frequently causes severe complications affecting multiple organs in newborns. Early recognition and management are crucial for improving outcomes in affected infants.

    Area of Science:

    • Neonatal Medicine
    • Pediatric Pathology
    • Obstetrics

    Background:

    • Perinatal asphyxia is a significant cause of neonatal morbidity and mortality.
    • Understanding the systemic impact of birth asphyxia is critical for effective clinical management.

    Purpose of the Study:

    • To describe the clinical and pathological consequences of perinatal asphyxia in a cohort of neonates.
    • To highlight the frequency and range of systemic complications following birth asphyxia.

    Main Methods:

    • Retrospective case series analysis.
    • Review of clinical records and pathological findings.
    • Study conducted at Howard University Hospital over 18 months, involving 17 neonates.

    Main Results:

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    • 76.5% of neonates experienced multiple systemic complications.
    • All major organ systems were affected, either individually or concurrently.
    • Complications ranged from mild to severe, impacting overall neonatal health.

    Conclusions:

    • Systemic complications are a common and serious sequela of perinatal asphyxia.
    • Comprehensive understanding of asphyxia's impact is vital for neonatal care providers.
    • Prenatal and intrapartum care providers must be aware of potential neonatal consequences.