Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bleomycin in testicular teratomas.

K W Brunner, R W Sonntag

    Zeitschrift Fur Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
    |November 25, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adjuvant therapy after excision and radiation of isolated postmastectomy locoregional breast cancer recurrence: definitive results of a phase III randomized trial (SAKK 23/82) comparing tamoxifen with observation.

    Annals of oncology : official journal of the European Society for Medical Oncology·2003
    Same author

    Fertility and sexual function following orchiectomy and 2 cycles of chemotherapy for stage I high risk nonseminomatous germ cell cancer.

    The Journal of urology·2001
    Same author

    Risk adapted management with adjuvant chemotherapy in patients with high risk clinical stage i nonseminomatous germ cell tumor.

    The Journal of urology·2000
    Same author

    Long-term results following adjuvant chemotherapy in patients with clinical stage I testicular nonseminomatous malignant germ cell tumors with high risk factors.

    The Journal of urology·1999
    Same author

    ["primum nil nocere" and clinical cancer research. Observations on a controversy].

    Schweizerische medizinische Wochenschrift·1994
    Same author

    Present and future projects of the International Breast Cancer Study Group.

    Cancer·1994
    Same journal

    Nephroblastoma and neuroblastoma--histology and prognosis.

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    Same journal

    Tumor cell interactions in vitro microtubules, 100 angstrom filaments, and contractile microfilaments of tumor cells involved in "emperipolesis".

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    Same journal

    In vitro studies of human breast carcinoma cells obtained by aspiration biopsy.

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    Same journal

    Microangiopathic haemolytic anaemia in cancer patients with bone marrow infiltration.

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    Same journal

    Release of glycolytic enzymes from cultivated tumor cells.

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    Same journal

    Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.

    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology·1978
    See all related articles

    Bleomycin and CCNU combination therapy showed a 59% remission rate in metastatic testicular teratoma patients. Complete remission is key for long-term survival, suggesting sequential drug combinations may improve outcomes.

    Area of Science:

    • Oncology
    • Medical Research

    Background:

    • Metastatic testicular carcinomas, excluding seminomas, are treated with bleomycin-based regimens.
    • Adjuvant postoperative therapy for stage II disease may benefit from bleomycin combinations.

    Purpose of the Study:

    • To evaluate the efficacy of a Bleomycin and CCNU combination in treating metastatic testicular teratoma.
    • To assess remission rates and duration in patients receiving this combination therapy.

    Main Methods:

    • A study involving 17 patients with metastatic testicular teratoma.
    • Treatment administered included a combination of Bleomycin and CCNU.

    Main Results:

    • A 59% remission rate was observed in the patient cohort.
    • Satisfactory remission duration was only achieved in patients with complete remission.

    Related Experiment Videos

    Conclusions:

    • The combination of Bleomycin and CCNU demonstrates a notable remission rate for metastatic testicular teratoma.
    • Sequential combination chemotherapy utilizing all effective drugs offers a promising strategy for enhancing remission rates and survival in testicular cancer.
    • Further research into sequential combination therapies is warranted to optimize treatment outcomes.