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[Serological classification of post-transfusion hepatitis (author's transl)]
Immunitat Und Infektion
|December 1, 1979
Summary
Post-transfusion hepatitis (PTH) is a significant risk following massive blood transfusions, observed in 38% of cardiac surgery patients. Diagnosis requires a combination of clinical, biochemical, and serological evidence.
Area of Science:
- Hepatology
- Infectious Diseases
- Transfusion Medicine
Background:
- Post-transfusion hepatitis (PTH) poses a significant risk after massive blood transfusions.
- The clinical presentation of PTH can be mild but prolonged.
Purpose of the Study:
- To determine the frequency and characteristics of post-transfusion hepatitis (PTH) in patients undergoing cardiac surgery with massive blood transfusions.
- To evaluate the diagnostic criteria for PTH.
Main Methods:
- Retrospective analysis of 141 cardiac surgery patients who received massive blood transfusions.
- Clinical assessment, biochemical tests, and serological testing (HBs-Ag, anti-HBs) for hepatitis B virus markers.
Main Results:
- The frequency of PTH was 38% in the studied cohort.
- Hepatitis B surface antigen (HBs-Ag) identified 46% of PTH cases as type B hepatitis.
- Anti-HBs antibodies were present in 39% of PTH cases, and 15% remained unclassified.
- HBs-Ag or anti-HBs were detected in 40% of patients without overt hepatitis symptoms.
Conclusions:
- PTH is a common complication following massive transfusions in cardiac surgery.
- Diagnosis of PTH necessitates a comprehensive evaluation including clinical symptoms, biochemical data, and serological markers.
- Hepatitis B virus markers are frequently detected in patients with and without clinical evidence of PTH.