Related Experiment Video
Updated: Aug 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Staphcoccomycin, a new basic macrolide antibiotic
Abstract:
Staphcoccomycin (SCM) is a new member of the basic macrolide family of antibiotics which was isolated from the fermentation broth of Streptomyces sp. AS-NG 16. The production, purification and determination of physical and chemical properties of this novel metabolite have been completed. Comparison of the mass fragmentation patterns of SCM and its peracetate with those of angolamycin peracetate suggested a des-mycarosyl derivative of angolamycin. Moreover, the molecular ion peak (m/e 771) corresponded to C39H65NO14 and the 1H-NMR of SCM was also consistent with the proposed structure.
Related Concept Videos
Bacterial Phylum Actinobacteria
Staphylococcal Skin Infections
Inhibitors of Gram-positive Cell Wall Synthesis
Inhibitors of Bacterial Protein Synthesis
Antifungal Agents
Clinical Significance of Antibiotic Resistance

