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Updated: Jul 9, 2026
12:33
A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
Published on: June 25, 2014
Summary
Pancreatic exocrine function tests and plasma insulin curves reveal impaired exocrine function in chronic pancreatitis. These tests may aid in diagnosing pancreatic disorders, including diabetes mellitus linked to chronic pancreatitis.
Area of Science:
- Gastroenterology
- Endocrinology
- Diabetology
Background:
- Pancreatic function tests are crucial for diagnosing pancreatic diseases.
- Assessing both exocrine and endocrine functions provides a comprehensive view of pancreatic health.
- Diabetes mellitus can be associated with underlying pancreatic pathology.
Purpose of the Study:
- To evaluate pancreatic exocrine function and plasma insulin response in patients with pancreatic disorders.
- To determine the diagnostic utility of these tests in identifying chronic pancreatitis and related conditions.
- To explore the relationship between impaired insulin production and pancreatic exocrine dysfunction.
Main Methods:
- Performed pancreatic exocrine function tests and glucose-loaded plasma insulin curves on 74 patients.
- Categorized patients into groups: no significant pancreatic disease, various pancreatic disorders, and postmature diabetes mellitus.
- Analyzed results in relation to specific pancreatic conditions.
Main Results:
- All patients with chronic pancreatitis and chronic relapsing pancreatitis showed impaired exocrine function.
- Insulin production defects were observed in 7/10 with chronic pancreatitis and 1/7 with chronic relapsing pancreatitis.
- Two patients with diabetes mellitus and flat plasma insulin curves were diagnosed with chronic pancreatitis.
Conclusions:
- Pancreatic exocrine function tests and plasma insulin response curves are valuable diagnostic tools for pancreatic diseases.
- Impaired exocrine function is a consistent finding in chronic pancreatitis.
- These tests can help identify chronic pancreatitis in patients presenting with diabetes mellitus.
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