[Pathomorphological studies of experimental thiazole-80 poisoning in sheep]

Investigations on the pathomorphological changes occurring in the organisms of 4 sheep poisoned experimentally by varying Thiazole-80 doses applied orally were made. It was established macroscopically that after opening the rumen a smell of sulfuric hydrogen is felt. The abomasum was with rusty brown haemorrhages and liver distrophy as well as enlarged gall bladder were observed. The histological studies of parenchymal organs revealed vascular disturbances, hyperemia, oedema and intervascular haemolysis. A heavy diffuse nephrosis, hyaline and protein cylinders were found in the kidney cortex, while in the ganglial cells of medula oblongata were evident degenerative changes. Histochemically, in sheep poisoned by thiazole-80, a well expressed reaction to iron in the lungs, leptomeniges and distrophic hepatocytes were established. Glycogen quantity in the liver was considerably reduced.