Related Experiment Video

Updated: May 5, 2026

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

8.8K

The effect of cardiac disease on hemoglobin-oxygen binding

R D Woodson, J D Torrance, S D Shappell

    The Journal of Clinical Investigation
    |July 1, 1970
    PubMed

    Insights

    In heart disease, reduced hemoglobin-oxygen affinity correlates with worsening cardiac function. This adaptation helps manage limited oxygen supply, with 2,3-DPG levels regulating affinity.

    Area of Science:

    • Cardiology
    • Physiology
    • Biochemistry

    Background:

    • Cardiac functional impairment affects oxygen delivery.
    • Hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) are key in oxygen transport.
    • Understanding these relationships is crucial for managing heart disease.

    Purpose of the Study:

    • To investigate the relationship between cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-DPG.
    • To identify adaptive mechanisms in patients with noncyanotic heart disease.

    Main Methods:

    • Studied 39 patients with noncyanotic heart disease.
    • Assessed cardiac function using cardiac index, arteriovenous oxygen (A-V O(2)) difference, and cardiac symptoms.
    • Measured hemoglobin-oxygen affinity, 2,3-DPG levels, and mixed venous blood oxygen saturation (S[unk]V(VO2)).

    Main Results:

    • A progressive decline in hemoglobin-oxygen affinity was observed with worsening cardiac function.
    • This alteration in hemoglobin-oxygen binding serves as an adaptive mechanism for limited oxygen supply.
    • A significant correlation was found between S[unk]V(VO2), 2,3-DPG, and the oxygen dissociation curve.

    Conclusions:

    • Reduced hemoglobin-oxygen affinity is a compensatory response to impaired cardiac function.
    • 2,3-DPG levels appear to be a critical in vivo regulator of hemoglobin-oxygen affinity.
    • These findings highlight important physiological adaptations in heart disease patients.

    More Related Videos

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

    Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

    Published on: November 5, 2019

    11.2K
    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction08:35

    Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

    Published on: August 17, 2022

    3.1K

    Related Concept Videos

    Hemoglobin01:24

    Hemoglobin

    Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
    When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
    8.8K
    Imbalances in Cardiac Output01:26

    Imbalances in Cardiac Output

    The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
    CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
    3.3K
    Factors Affecting Erythropoiesis01:24

    Factors Affecting Erythropoiesis

    The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
    Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
    EPO then...
    8.4K
    Oxygen Transport in the Blood01:27

    Oxygen Transport in the Blood

    Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
    8.3K
    Hypoxia01:23

    Hypoxia

    Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
    Types of Hypoxia
    There are four primary types of hypoxia, each resulting from a different cause:
    1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
    2.4K
    Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

    Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

    Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
    386