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Relationship of infantile vesicoureteric reflux to renal damage
British Medical Journal
|February 21, 1970
Insights
Infants with gross vesicoureteric reflux (VUR) face a high risk of kidney damage. Moderate or slight VUR in infants did not show progressive renal damage over five years.
Area of Science:
- Pediatric Nephrology
- Urology
- Clinical Medicine
Background:
- Vesicoureteric reflux (VUR) is a common condition in infants.
- The severity of VUR may influence renal outcomes.
- Long-term effects of VUR on kidney health require further investigation.
Purpose of the Study:
- To assess the long-term renal outcomes in infants with varying degrees of VUR.
- To determine the correlation between VUR severity and the incidence of renal damage.
- To identify risk factors for progressive renal damage in infants with VUR.
Main Methods:
- A five-year follow-up study of infants diagnosed with VUR.
- Classification of VUR severity (gross, moderate, slight).
- Monitoring for initial and progressive renal damage.
Main Results:
- Infants with gross VUR exhibited a high incidence of initial and progressive renal damage.
- No progressive renal damage was observed in infants with moderate or slight VUR.
- A significant association between severe VUR and adverse renal outcomes was noted.
Conclusions:
- Gross VUR in infancy is a significant risk factor for progressive renal damage.
- Moderate and slight VUR may have a more favorable prognosis regarding renal damage.
- Early identification and management of severe VUR are crucial for preventing long-term kidney complications.
Abstract:
A group of patients known to have had vesicoureteric reflux of varying severity in infancy were followed up over a period of five years. Gross vesicoureteric reflux was found to be accompanied by a high incidence of initial and progressive renal damage. Progressive renal damage was not found in infants showing moderate or slight reflux.