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Summary
Mezlocillin (Baypen) concentrations in hip surgery patients reached therapeutic bone levels within 30 minutes post-injection. However, azlocillin showed higher concentrations, suggesting potential efficacy differences in bone penetration.
Area of Science:
- Pharmacology
- Orthopedic Surgery
- Infectious Disease
Context:
- Extended hip surgery poses infection risks.
- Effective antibiotic bone penetration is crucial for preventing surgical site infections.
- Acylureido-penicillins are used for severe bacterial infections.
Purpose:
- To determine mezlocillin bone and blood concentrations after intravenous administration in hip surgery patients.
- To compare mezlocillin bone concentrations with established therapeutic ranges.
- To compare mezlocillin bone concentrations with those of azlocillin.
Summary:
- Twenty patients received a single 2g intravenous dose of mezlocillin (Baypen).
- Blood and bone (spongiosa) samples were collected at various times post-injection.
- Peak bone concentrations averaged 20 microgram/g at 30 minutes, falling within the therapeutic range.
- Azlocillin, another acylureido-penicillin, demonstrated comparatively higher bone concentrations.
Impact:
- Provides crucial pharmacokinetic data for mezlocillin in orthopedic surgical settings.
- Informs antibiotic selection for preventing bone infections post-hip surgery.
- Highlights potential differences in bone penetration between mezlocillin and azlocillin.