Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in arterial pressure following heparin injection prior to cardiopulmonary bypass.

J L Seltzer, J I Gerson

    Acta Anaesthesiologica Scandinavica
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Regulation of gelatinase in human skin organ cultures by glucocorticoids.

    The Journal of investigative dermatology·2010
    Same author

    Multicenter study of contaminated percutaneous injuries in anesthesia personnel.

    Anesthesiology·1998
    Same author

    Protein tyrosine phosphorylation in signalling pathways leading to the activation of gelatinase A: activation of gelatinase A by treatment with the protein tyrosine phosphatase inhibitor sodium orthovanadate.

    Biochimica et biophysica acta·1998
    Same author

    Activation of gelatinase A (72-kDa type IV collagenase) induced by monensin in normal human fibroblasts.

    Experimental cell research·1997
    Same author

    Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts.

    Proceedings of the National Academy of Sciences of the United States of America·1997
    Same author

    Medical waste in the environment: do anesthesia personnel have a role to play?

    Journal of clinical anesthesia·1996
    Same journal

    Impact of Higher Versus Lower Blood Pressure Targets on Pulmonary Vascular Hemodynamics During Intensive Care After Out-of-Hospital Cardiac Arrest.

    Acta anaesthesiologica Scandinavica·2026
    Same journal

    Early Labour Epidural for Parturients With High BMI-A National Danish Survey.

    Acta anaesthesiologica Scandinavica·2026
    Same journal

    Contrast Media and Acute Kidney Injury in the ICU.

    Acta anaesthesiologica Scandinavica·2026
    Same journal

    The Impact of Diuretics on Mortality in Acute Kidney Injury With or Without Fluid Accumulation in Intensive Care-A Retrospective Cohort Study.

    Acta anaesthesiologica Scandinavica·2026
    Same journal

    Authors' Response to "Vasopressors in Early Burn Resuscitation: Physiological Concerns Revisited".

    Acta anaesthesiologica Scandinavica·2026
    Same journal

    Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE-A Cohort of 1.2 Million Surgeries.

    Acta anaesthesiologica Scandinavica·2026
    See all related articles

    Beef-lung heparin administration significantly lowered arterial blood pressure in most patients undergoing cardiopulmonary bypass. This blood pressure reduction is likely due to decreased systemic vascular resistance, not changes in heart rate.

    Area of Science:

    • Cardiovascular Pharmacology
    • Anesthesiology

    Background:

    • Heparin is known to possess vasodilating properties.
    • The hemodynamic effects of heparin, particularly in the context of cardiopulmonary bypass, require further elucidation.

    Purpose of the Study:

    • To investigate the arterial blood pressure changes following beef-lung heparin administration before cardiopulmonary bypass.
    • To determine the underlying hemodynamic mechanisms responsible for observed blood pressure alterations.

    Main Methods:

    • Prospective observational study involving 43 patients undergoing cardiopulmonary bypass.
    • Administration of 300 units/kg of beef-lung sodium heparin prior to bypass.
    • Monitoring of arterial blood pressure, heart rate, and calculation of cardiac output and systemic vascular resistance in a subset of patients.

    Related Experiment Videos

    Main Results:

    • A significant decrease in arterial blood pressure was observed in 37 out of 43 patients post-heparin administration.
    • Systolic blood pressure decreased by approximately 10 mmHg and diastolic by 5 mmHg.
    • No significant changes in heart rate were noted; calculations suggested a reduction in systemic vascular resistance as the primary cause of hypotension.

    Conclusions:

    • Beef-lung sodium heparin administration induces a hypotensive effect prior to cardiopulmonary bypass.
    • The primary mechanism appears to be a decrease in systemic vascular resistance.
    • These findings highlight an important hemodynamic consideration for anesthetic management during cardiac surgery.