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Related Experiment Videos

Cefaclor--summary of clinical experience.

R B Kammer, L J Short

    Postgraduate Medical Journal
    |January 1, 1979
    PubMed
    Summary

    Cefaclor, an oral cephalosporin antibiotic, demonstrated high efficacy across various infections, including respiratory and skin conditions. It showed a low incidence of adverse reactions, making it a promising treatment option.

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    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Cefaclor is an oral, semisynthetic cephalosporin antibiotic.
    • The study aimed to evaluate its efficacy and safety in a large patient cohort.

    Purpose of the Study:

    • To assess the clinical effectiveness of cefaclor in treating various infections.
    • To determine the safety profile of cefaclor in adult and pediatric patients.

    Main Methods:

    • A multicenter study involving 62 investigators across 6 countries.
    • 1493 adult and pediatric patients with various infections were treated with cefaclor.

    Main Results:

    • Satisfactory clinical response rates included 80% for urinary tract infections, 87% for upper respiratory infections, 90% for otitis media, 99% for lower respiratory tract infections, and 96% for skin infections.
    • Low incidence of adverse reactions: gastrointestinal (2.6%) and hypersensitivity (1.5%).
    • Particularly notable efficacy in otitis media and lower respiratory tract infections.

    Conclusions:

    • Cefaclor is an effective oral antibiotic for a range of common infections.
    • The antibiotic exhibits a favorable safety profile with minimal adverse effects.
    • Its high success rates in treating otitis media and lower respiratory tract infections warrant clinical consideration.

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