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Evidence for aluminium accumulation in renal failure
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1979
Summary
Patients with chronic renal failure show elevated serum aluminium levels, especially when using aluminium-based phosphate binders. This accumulation poses risks for serious health issues like bone disease and brain dysfunction.
Area of Science:
- Nephrology
- Clinical Chemistry
- Toxicology
Background:
- Growing evidence links aluminium accumulation in renal impairment to adverse health effects.
- Impaired kidney function can lead to the buildup of toxic substances, including aluminium.
- Aluminium exposure is a concern for patients with reduced kidney function.
Purpose of the Study:
- To investigate serum aluminium levels in patients with chronic renal failure.
- To assess the impact of aluminium-containing phosphate binders on aluminium accumulation.
- To evaluate the potential risks associated with long-term aluminium exposure in renal patients.
Main Methods:
- Serum aluminium levels were measured in 45 patients with chronic renal failure.
- Comparison of aluminium levels between patients and normal subjects.
- Analysis of aluminium levels in patients using aluminium-containing phosphate binders.
Main Results:
- Serum aluminium content was significantly higher in patients with chronic renal failure compared to healthy individuals.
- Patients taking aluminium-containing phosphate binders exhibited a further increase in serum aluminium concentration.
- Long-term use of these binders in moderately impaired renal function may lead to significant aluminium accumulation.
Conclusions:
- Chronic renal failure is associated with elevated serum aluminium.
- Aluminium-containing phosphate binders exacerbate aluminium accumulation in renal patients.
- Patients with impaired renal function on these binders are at risk for aluminium-induced osteomalacia and encephalopathy.