Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Red cell 2,3-DPG levels in diabetic vasculopathy.

A Puxeddu, P Brunetti, G Calabrese

Acta Diabetologica Latina

|October 1, 1979

Summary

Increased red blood cell 2,3-diphosphoglycerate (2,3-DPG) levels are linked to arterial vasculopathy in both diabetics and non-diabetics. This elevation appears to be a consequence of vascular disease, not diabetes itself.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erratum: Comprehensive analysis of the self-assembled formation of GaN nanowires on amorphous Al<i>x</i>O<i>y</i>:<i>in situ</i>quadrupole mass spectrometry studies (2019<i>Nanotechnology</i><b>30</b>154002).

Nanotechnology·2026

Same author

Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes.

Journal of endocrinological investigation·2024

Same author

Experimental characterization of gaseous ion beams produced with the advanced ion source for hadrontherapy (AISHa) at 18 GHz.

The Review of scientific instruments·2023

Same author

Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae: Analysis of cases and evaluation of in vitro activity of fosfomycin-containing combinations.

Journal of global antimicrobial resistance·2023

Same author

Trocar vs. Seldinger small bore pleural drains: does the technique influence the outcomes? A prospective single-centre study.

European review for medical and pharmacological sciences·2023

Same author

Is itching in atopic dermatitis still an unmet need? A case series of 556 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022

Area of Science:

Biochemistry
Vascular Biology
Diabetology

Background:

Arterial vasculopathy is a common complication in diabetes.
Red blood cell 2,3-diphosphoglycerate (2,3-DPG) influences oxygen delivery.
The relationship between vasculopathy, diabetes, and 2,3-DPG requires clarification.

Purpose of the Study:

To investigate the levels of RBC 2,3-DPG in diabetic and non-diabetic patients with arterial vasculopathy.
To determine if diabetes or vasculopathy is the primary driver of altered RBC 2,3-DPG levels.

Main Methods:

Comparative analysis of RBC 2,3-DPG levels.
Inclusion of three patient groups: insulin-dependent diabetics with vasculopathy, non-diabetic vasculopathic patients, and insulin-dependent diabetics without vascular involvement.

Related Experiment Videos

Comparison against normal subject levels.

Main Results:

RBC 2,3-DPG was statistically increased in insulin-dependent diabetics with arterial vasculopathy compared to normal subjects.
RBC 2,3-DPG was also statistically increased in non-diabetic patients with vasculopathy.
No significant difference in RBC 2,3-DPG was observed in insulin-dependent diabetics without vascular involvement.

Conclusions:

The observed increase in RBC 2,3-DPG is primarily a consequence of arterial vasculopathy.
Diabetes alone, in the absence of vascular complications, does not appear to elevate RBC 2,3-DPG.
RBC 2,3-DPG may serve as a biomarker related to the severity of vasculopathy.