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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Published on: January 28, 2020

Serum antithrombin in coronary-artery disease

I Innerfield, J D Goldfischer, H Reicher-Reiss

    American Journal of Clinical Pathology
    |January 1, 1976
    PubMed

    Insights

    Serum antithrombin activity (AA) correlates with coronary artery disease severity. Low AA in angina patients may indicate significant blockages, suggesting a need for clot-preventive therapies.

    Area of Science:

    • Cardiology
    • Hematology

    Background:

    • Coronary artery disease (CAD) is a leading cause of mortality.
    • Antithrombin activity (AA) plays a crucial role in regulating blood coagulation.

    Purpose of the Study:

    • To investigate the relationship between serum antithrombin activity (AA) and coronary angiographic findings in patients with angina.
    • To determine if AA levels can predict the severity of coronary artery disease.

    Main Methods:

    • Serum antithrombin activity (AA) was measured in 69 patients with documented angina.
    • Coronary angiography was performed to assess the extent of coronary artery stenosis.
    • Patients were grouped based on AA levels (normal, high, or low).

    Main Results:

    • A strong correlation was observed between normal or high AA levels (>90%) and normal coronary circulation or single-vessel stenosis (86% and 90% of patients, respectively).
    • Significantly decreased AA values were found in 24 patients, with 90% of this group exhibiting two or three-vessel occlusions.
    • Low AA levels were associated with severe coronary artery disease (CAD).

    Conclusions:

    • Serum antithrombin activity (AA) is a potential biomarker for assessing coronary artery disease severity in angina patients.
    • Low AA levels in angina patients may indicate significant CAD and a "turned-on" clotting system.
    • AA estimation can identify patients who may benefit from clot-preventive measures like aspirin, dipyridamole, or anticoagulants.

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