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[Pharmacokinetics of mezlocillin in the rabbit eye]
Abstract:
Following intravenous injection of 50 mg/kg Mezlocillin into rabbit eyes the concentrations measured in the aqueous humor were of low-grade therapeutic efficacy. In the vitreous, this dose and form of application had no therapeutic effect. The transfer concentration in the aqueous humor after subconjunctival application of 20 mg Mezlocillin was comparably low. High therapeutic levels in the aqueous humor and even, in isolated cases, traces of Mezlocillin in the vitreous were found after subconjunctival injection of 100 mg.
Insights
Intravenous Mezlocillin showed low therapeutic efficacy in rabbit aqueous humor and none in the vitreous. Subconjunctival injection of 100 mg Mezlocillin achieved high therapeutic levels in the aqueous humor and vitreous.
Area of Science:
- Ophthalmology
- Pharmacology
- Microbiology
Context:
- Evaluating antibiotic penetration into ocular tissues is crucial for treating eye infections.
- Mezlocillin is an antibiotic used to treat bacterial infections.
Purpose:
- To determine the intraocular penetration and therapeutic efficacy of Mezlocillin after intravenous and subconjunctival administration in rabbits.
Summary:
- Intravenous injection of 50 mg/kg Mezlocillin resulted in low therapeutic concentrations in the aqueous humor and no effect in the vitreous.
- Subconjunctival administration of 20 mg Mezlocillin showed low aqueous humor concentrations.
- Subconjunctival injection of 100 mg Mezlocillin achieved high therapeutic levels in the aqueous humor and detectable levels in the vitreous.
Impact:
- Subconjunctival injection of higher doses of Mezlocillin may be a viable strategy for treating ocular infections.
- Results inform potential clinical applications of Mezlocillin in ophthalmology.