[Allergic reactions in cytostatic therapy]

The cytostatics used in treatment of malignant diseases may, similar to other drugs sensibilize the organism and cause various allergic manifestations. The authors present 6 children with malignant diseases in whom various allergic reactions, from urticaria to a severe form of Stivens-Johnson syndrome, were observed to appear during the treatment with cytostatics. All symptoms of allergy withdrew after the administration of antihistaminics. Difficulties in differential diagnosis of an allergy and tocsic effects of cytostatics are also pointed out.