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[Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author's transl)]
Anesthesie, Analgesie, Reanimation
|January 1, 1979
Abstract:
The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency. The mechanism is a matter of speculation, but the most attractive view is that the inhibiting effect of trimethoprim on dehydrofolate reductase can involve pancytopenia in patients with folic acid deficiency.