Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Developing Myopia in a Mouse Model Through Lens-Induced Defocusing02:48

Developing Myopia in a Mouse Model Through Lens-Induced Defocusing

750
Source: Jiang, X., et al. Inducement and evaluation of a murine model of experimental myopia. J. Vis. Exp. (2019)This video demonstrates a procedure for inducing myopia in a mouse through the installation of a custom lens frame. The frame is secured to the exposed skull with dental adhesive, and concave lenses are inserted to shift the focal point behind the retina. This setup stimulates eyeball elongation leading to...
750
Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model07:37

Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model

1.8K
This protocol presents a transpupillary vision-guided trans-scleral approach to safely and precisely deliver subretinal cellular grafts, with a low rate of surgical complications, in mouse recipients with or without retinal...
1.8K
Inducement and Evaluation of a Murine Model of Experimental Myopia07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

10.5K
In this protocol, we describe the full process of experimental myopia inducement in mice using newly designed eyeglasses and the technic needed for achieving stable and reproducible results in ocular parameter...
10.5K
Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish06:27

Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish

10.4K
The zebrafish is a popular animal model to study mechanisms of retinal degeneration/regeneration in vertebrates. This protocol describes a method to induce localized injury disrupting the outer retina with minimal damage to the inner retina. Subsequently, we monitor in vivo the retinal morphology and the Müller glia response throughout retinal...
10.4K
Methylnitrosourea (MNU)-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics08:53

Methylnitrosourea (MNU)-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

12.0K
Herein we demonstrate quantification of retinal de- and regeneration and its impact on visual function using N-methyl-N-nitrosourea in the adult zebrafish. Loss of visual acuity and decreased photoreceptor numbers were followed by proliferation in the inner nuclear layer. Complete morphological and functional regeneration occurred 30 days after the initial...
12.0K
Modeling Retinal Degeneration and Regeneration in Zebrafish Using a Focal Laser Injury02:56

Modeling Retinal Degeneration and Regeneration in Zebrafish Using a Focal Laser Injury

659
This video demonstrates a procedure to induce retinal degeneration in adult zebrafish using laser injury. The laser targets photoreceptor cells in the retina, triggering cell death and a degenerative process. This damage activates Müller glia (MG) cells, leading to their dedifferentiation into stem cell progenitors that aid in retinal...
659

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sebaceous neoplasm in the lung of a dog.

Australian veterinary journal·2025
Same author

Associative white matter tracts selectively predict sensorimotor learning.

Communications biology·2024
Same author

Associative white matter tracts selectively predict sensorimotor learning.

bioRxiv : the preprint server for biology·2023
Same author

Periosteal chondroid tumors: radiologic evaluation with pathologic correlation.

AJR. American journal of roentgenology·2001
Same author

Imaging findings in pseudocystic osteosarcoma.

AJR. American journal of roentgenology·2001
Same author

Tibial turn-up for long distal femoral bone loss.

Clinical orthopaedics and related research·2001

Related Experiment Video

Updated: Jan 20, 2026

Developing Myopia in a Mouse Model Through Lens-Induced Defocusing
02:48

Developing Myopia in a Mouse Model Through Lens-Induced Defocusing

Published on: April 28, 2025

750

Peripheral retinal degeneration in high myopia

G E Kirker, D J McDonald

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |January 1, 1971
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
    07:37

    Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model

    Published on: January 26, 2024

    1.8K
    Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics
    08:53

    Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

    Published on: October 20, 2014

    12.0K

    Related Experiment Videos

    Last Updated: Jan 20, 2026

    Developing Myopia in a Mouse Model Through Lens-Induced Defocusing
    02:48

    Developing Myopia in a Mouse Model Through Lens-Induced Defocusing

    Published on: April 28, 2025

    750
    Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model
    07:37

    Transpupillary-Guided Trans-Scleral Transplantation of Subretinal Grafts in a Retinal Degeneration Mouse Model

    Published on: January 26, 2024

    1.8K
    Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics
    08:53

    Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

    Published on: October 20, 2014

    12.0K