Noneffect of oral urinary copper ascorbic acid on reduction glucose test.

Area of Science:

• Clinical Chemistry
• Endocrinology
• Nutritional Science

Background:

• Ascorbic acid (vitamin C) is a known reducing agent.
• Previous studies suggested ascorbic acid causes false-positive results in copper reduction glucose tests.
• This interference was theorized due to ascorbic acid's chemical properties.

Purpose of the Study:

• To investigate whether high oral doses of ascorbic acid cause false-positive results in the copper reduction glucose test.
• To re-evaluate the commonly held belief regarding ascorbic acid interference with glucose detection.

Main Methods:

• 10 healthy nondiabetic men participated in the study.
• Participants ingested daily doses of 4 and 6 grams of ascorbic acid.
• A total of 360 copper reduction glucose tests (Clinitest) were performed.

Main Results:

• No false-positive glucose test results were observed in any of the 360 tests conducted.
• Ingesting high doses of ascorbic acid did not interfere with the copper reduction method for glucose detection.

Conclusions:

• The study found no evidence that high oral intake of ascorbic acid leads to false-positive results in the copper reduction glucose test.
• This challenges the established notion of ascorbic acid interference with this specific glucose testing method.